Carlos Santana and Becky G are using music to spotlight one of the most painful realities affecting Latino families in the United States. Their new collaboration, “Mi gran amor,” arrives with a message rooted in love, fear, resilience, and the emotional weight carried by immigrant communities facing detention and family separation. The song premieres Thursday, May 28, at 8 p.m. ET and blends Santana’s rock guitar style with contemporary Latin influences. Produced and co-written by acclaimed hitmaker Edgar Barrera, the track balances urgency and vulnerability. For Santana, “Mi gran amor” represents more than another musical release. It marks a defining moment in the legendary guitarist’s upcoming creative era as the third single from his next album. Speaking to Billboard Español before a performance in Detroit, Santana explained the emotional intention behind the music and the role his guitar plays throughout the song.